The effect of ultrafiltration transmembrane permeation on the flow field in a surrogate system of an artificial kidney

Abstract Renal Replacement Therapies generally associated to the Artificial Kidney (AK) are membrane-based treatments that assure separation functions of failing kidney in extracorporeal blood circulation. Their progress from conventional hemodialysis towards high-flux (HFHD) through introduction ultrafiltration membranes characterized by high convective permeation fluxes intensified need elucidating effect membrane fluid removal rates on increase potentially blood-traumatizing shear stresses developed adjacently membrane. The AK surrogate consisting two-compartments separated an is set have water circulation upper chamber mimicking flow and typical HFHD. Pressure drop mirrors quantification modification velocities profiles. pressure when comparing flows slits with a permeable impermeable wall ca. 512% 576% for $ \mathrm{CA}22/5\%{\mathrm{SiO}}_2 \mathrm{CA}30/5\%{\mathrm{SiO}}_2 membranes, respectively.